Friday, December 23, 2005

ABVD Chemo drugs.

I'm having a hard time keeping track of all this crap so I thought I would post it here for reference purposes.

Adriamycin (generic name doxorubicin)
Bleomycin (common brand name blenoxane)
Vinblastine (common brand names velban, velsar, velbe)
Dacarbazine (common brand names DTIC, DTIC-Dome)

Adriamycin
It is is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius. As such, it is an antineoplastic - adriamycin interferes with the growth of cancer cells. It is one of the older chemotherapy drugs, having been in use for decades for several types of cancer.

Short Term Side Effects: Common: nausea and vomiting (ask your doctor about drugs to counteract nausea), sores on mouth & lips; Less Common: cough, fever/chills, fast or irregular heartbeat, swelling of extremities, diarrhea; Rare: black stools, blood in urine, pinpoint red spots on skin, unusual bleeding, wheezing, skin rash/itching. Adriamycin may turn the urine red which is not blood and should disappear within 2 days.

Long Term Side Effects: hair loss (alopecia) during use - hair growth should return late in treatment or after treatment, possible sterility (weaker than some drugs) and heart toxicity

Bleomycin
It is an antineoplastic - bleomycin is an antitumor antibiotic, interfering with the growth of cancer cells.

Short Term Side Effects: Common: nausea and vomiting (ask your doctor about drugs to counteract nausea), fever/chills after dose, cough, shortness of breath, mouth sores, itching, rash, loss of appetite; Less Common: confusion, faintness, wheezing; Rare: sudden/severe chest pain, sudden weakness in arms/legs

Long Term Side Effects: hair loss (alopecia) during use - hair growth should return after treatment and lung (pulmonary) toxicity

Vinblastine
An antineoplastic, vinblastine interferes with the growth of cancer cells - it does this by inhibiting microtubule production on cells. It is in the vinca alkaloid family. Originally derived from the Madagascar periwinkle plant Catharanthus roseus.

Short Term Side Effects: Common: nausea and vomiting (ask your doctor about drugs to counteract nausea), fever/chills after dose, cough, shortness of breath, mouth sores, itching, rash, loss of appetite; Less Common: confusion, faintness, wheezing, peripheral neuropathy (tingling & numbness in the hands and feet). Rare: sudden/severe chest pain, sudden weakness in arms/legs

Long Term Side Effects: hair loss (alopecia) during use - hair growth should return after treatment and lung (pulmonary) toxicity (doses should be monitored), peripheral neuropathy (tingling & numbness in the hands and feet).

Dacarbazine
An alkylating agent, it functions as a methylating agent after metabolic activation in the liver. Dacarbazine is also used to treat melanoma, a cancer of the skin.

Short Term Side Effects: Common: Redness, pain, or swelling at the site of injection, nausea, vomiting. Less Common: black stools, blood in urine or stool, cough, fever/chills, lower back/side pain, painful or difficult urination, pinpoint red spots on skin, sores in mouth and on lips.

Long Term Side Effects: Some hair loss which should return after treatment, transient (shorter term) reduction in liver and kidney function.

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